Hydroxy-α-sanshool

• Description :

  Hydroxy-α-sanshool is a transient receptor potential ankyrin 1 (TRPA1) and TRP vanilloid 1 (TRPV1) agonist with EC50s of 69 and 1.1 μM, respectively. Hydroxy-α-sanshool can be used for pain research[1][2].

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Endogenous Metabolite; TRP Channel

• Type :

  Natural Products

• Related Pathways :

  Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/hydroxy-alpha-sanshool.html

• Concentration :

  10mM

• Purity :

  99.57

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  C/C=C/C=C/C=C\CC/C=C/C(NCC(C)(O)C)=O

• Molecular Formula :

  C16H25NO2

• Molecular Weight :

  263.38

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Koo JY, et al. Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels. Br J Pharmacol. 2009 Aug;157 (8) :1398-409.|[2]Koo JY, et al. Hydroxy-alpha-sanshool activates TRPV1 and TRPA1 in sensory neurons. Eur J Neurosci. 2007 Sep;26 (5) :1139-47.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [83883-10-7]