5-HT2A/5-HT2C inverse agonist 1

5-HT2A/5-HT2C inverse agonist 1

• CAS Number: 2718990-76-0
• UNSPSC Description: 5-HT2A/5-HT2C inverse agonist 1 is a potent and dual 5-HT2A and 5-HT2C receptor inverse agonist with a hERG inhibitions, thus avoiding cardiovascular risks. 5-HT2A/5-HT2C inverse agonist 1 shows significant antipsychotic efficacy in the MK-801 (HY-15084B)-induced mouse model. 5-HT2A/5-HT2C inverse agonist 1 is promising for research of psychosis[1].
• Target Antigen: 5-HT Receptor
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/5-ht2a-5-ht2c-inverse-agonist-1.html
• Smiles: CN(C=C1)N=C1CN([C@@H]2C3(CN(CC2)C)CC3)C(NCC4=CC=C(C=C4)OCCC)=O
• Molecular Weight: 425.57
• References & Citations: [1]Oguma T, et al. Dual 5-HT2A and 5-HT2C Receptor Inverse Agonist That Affords In Vivo Antipsychotic Efficacy with Minimal hERG Inhibition for the Treatment of Dementia-Related Psychosis. J Med Chem. 2024 Aug 22;67(16):14478-14492.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported