RORγt Inverse agonist 10

RORγt Inverse agonist 10

• CAS Number: 2413986-35-1
• UNSPSC Description: RORγt Inverse agonist 10 is a potent and orally bioavailable RORγt (retinoic acid receptor-related orphan nuclear receptor gamma t) inverse agonist, with an IC50 of 51 nM. RORγt is a major transcription factor of genes related to psoriasis pathogenesis such as IL-17A, IL-22, and IL-23R[1]
• Target Antigen: ROR
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/rorγt-inverse-agonist-10.html
• Smiles: C[C@H](N(C(CC(C(F)(F)F)C(F)(F)F)=O)CC1)C[C@H]1OC2=C(C)C(NC(C3=CN=C(C)C=C3)=O)=CN4C2=NC=N4
• Molecular Weight: 572.50
• References & Citations: [1]Ryota Nakajima, et al. Discovery of [1,2,4]Triazolo[1,5- a]pyridine Derivatives as Potent and Orally Bioavailable RORγt Inverse Agonists. ACS Med Chem Lett. 2020 Feb 27;11(4):528-534.
• Shipping Conditions: Room Temperature