Mouse anti Human CD11b

Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Dry Ice Shipment: No

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CAT:

579-11B1

Size:

100 µg

Price:

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For price, please contact [email protected].

Mouse anti Human CD11b

Background: (Mac-1), CD11b/CD18 complex is a leukocyte adhesion receptor to intercellular adhesion molecules (ICAM's). CR3 alpha chain (M.W. 165,000) is on virtually all peripheral blood neutrophils, eosinophils, monocytes and approximately 30% of peripheral blood lymphocytes.
Synonyms: CD11b
UniProt: P11215
Host: Mouse
Species Reactivity: Human
Isotype: IgG2a
Clone: F6.2
Conjugation: Unconjugated
Type: Single-Color Reagent
Applications: Flow Cytometry
Field of Research: Flow Cytometry
Purification Method: Protein A/G Chromatography
Assay Principle: PBMC: Add10 µL of MAB/10^6 PBMC in 100 µL PBS. Mix gently and incubate for 15 minutes at 2 to 8º C. Wash twice with PBS and analyze or fix with 0.5% v/v of paraformaldehyde in PBS and analyze. WHOLE BLOOD: Add10 µL of MAB/100 µL of whole blood. Mix gently and incubate for 15 minutes at room temperature (20ºC). Lyse the whole blood. Wash once with PBS and analyze or fix with 0.5% v/v of paraformaldehyde in PBS and analyze. See instrument manufacturer’s instructions for Lysed Whole Blood and Immunofluorescence analysis with a flow cytometer or microscope.
Stability: See expiration date on vial
Concentration: See vial for Concentration
Form: Provided as solution in phosphate buffered saline with 0,08% sodium azide
Precautions: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
References & Citations: 1.Structure and function of the leukocyte adhesion molecules CD11/CD18. Arnaout, M.A., Blood . 1990 Mar; 75(5):1037-50. 2. Leukocyte adhesion to endothelial cells. Wautier, ,J.L., Sediadi, H., Vilette, d., Weill, D., Wautier, M.P.. Biorheology . 1990:27(34): 425-32. 3. Flow cytometric analysis of neutrophil subsets in thermally injured patients developing infection. Babcock, G.F., Alexander, J.W., Warden, G.d.. Clin. Immunol. Immunopathol. 1990 Ja;54(1):117-25. 4. Leukocyte Adhesion Deficiency: an inherited defect in Mac-1,LFA-1, and p150,95 glycoproteins. Anderson, D.C. and Springer, T.A.. Ann. Rev. Med. 1987;38:175. 5. Two pathways of CD11b/CD18-mediated neutrophil aggregation with different involvedment of protein kinase C-dependent phosphorylation. Merrill, J.T., Slade, S.G., Weissman, G., Winchester, R., Buyon, J.P.. J. Immunology. 1990 Oct.1;145(8):2608-15. 6. Tumor necrosis factor-induce degranulation in adherent Human neutrophils is dependent on CD11b/CD18-integrin-triggered oscillations of cytosolic free Ca2+. Richter, J., Ng-Sikorski, J., Olsson, I., Andersson, T.. Proc. Natl. Acad. Sci. USA 1990 De;87(23):9472-6.
Shipping Conditions: Room Temperature
Storage Conditions: Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
Functional Analysis: Flow Cytometry Staining

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