(S) -MDL-101146

CAT: 0804-HY-120039ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-120039ASize:1 Each
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Description
(S) -MDL-101146 is the S-isomer of MDL-101146. MDL-101146 is an orally active, competitive and reversible inhibitor against human neutrophil elastase (HNE) with a Ki value of 25 nM. MDL-101146 inhibits HNE-induced hemorrhage in hamsters. MDL-101146 is promising for research of emphysema, rheumatoid arthritis, chronic bronchitis, cystic fibrosis, adult respiratory distress syndrome and glomerulonephritis[1].
CAS Number
[163660-59-1]
UNSPSC
12352005
Target
Elastase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/s-mdl-101146.html
Smiles
O=C(NC([C@H](C(C)C)NC(C1=CC=C(C(N2CCOCC2)=O)C=C1)=O)=O)[C@H]3N([C@@H](C(C)C)C(C(F)(F)C(F)(F)F)=O)CCC3
Molecular Formula
C29H37F5N4O6
Molecular Weight
632.62
References & Citations
[1]Angelastro MR, et al. Inhibition of human neutrophil elastase with peptidyl electrophilic ketones. 2. Orally active PG-Val-Pro-Val pentafluoroethyl ketones. J Med Chem. 1994 Dec 23;37 (26) :4538-53.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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