ABT-770

• Description:

  ABT-770 (compound 11) is a highly selective and orally active MMP inhibitor, demonstrating over 1000-fold selectivity for MMP-2 (IC50=4 nM) compared to MMP-1 (IC50=4600 nM) . ABT-770 can be utilized in studies related to tumor growth, invasion, and metastasis[1].

• UNSPSC:

  12352005

• Target:

  MMP

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/abt-770.html

• Smiles:

  O=CN([C@@H](CN(C(NC1(C)C)=O)C1=O)COC2=CC=C(C3=CC=C(OC(F)(F)F)C=C3)C=C2)O

• Molecular Formula:

  C22H22F3N3O6

• Molecular Weight:

  481.42

• References & Citations:

  [1]Curtin, et al. "Discovery and characterization of the potent, selective and orally bioavailable MMP inhibitor ABT-770." Bioorganic & medicinal chemistry letters 11.12 (2001) : 1557-1560.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  MMP-1; MMP-2

• CAS Number:

  220614-50-6