MANS peptide (TFA)

• UNSPSC Description:

  MANS peptide TFA is the TFA salt form of MANS peptide (HY-P10218). MANS peptide TFA is an inhibitor for myristoylated alanine-rich C kinase substrate (MARCKS), which competes with MARCKS in cells for membrane binding, and thus inhibits the stimulation of mucin secretion and tumor metastasis[1].

• Target Antigen:

  MARCKS; PKC

• Type:

  Peptides

• Related Pathways:

  Cytoskeleton;Epigenetics;TGF-beta/Smad

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/mans-peptide-tfa.html

• Purity:

  96.06

• Solubility:

  DMSO : 13.3 mg/mL (ultrasonic)

• Smiles:

  CCCCCCCCCCCCCC(NCC(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CCCCN)C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N2[C@@H](CCC2)C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.O=C(C(F)(F)F)O.[x]

• Molecular Weight:

  2498.83 (free acid)

• References & Citations:

  [1]Chen CH, et al., A peptide that inhibits function of Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) reduces lung cancer metastasis. Oncogene. 2014 Jul 10;33(28):3696-706.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported