MANS peptide (TFA)

• Description :

  MANS peptide TFA is the TFA salt form of MANS peptide (HY-P10218) . MANS peptide TFA is an inhibitor for myristoylated alanine-rich C kinase substrate (MARCKS), which competes with MARCKS in cells for membrane binding, and thus inhibits the stimulation of mucin secretion and tumor metastasis[1].

• UNSPSC :

  12352209

• Target :

  MARCKS; PKC

• Type :

  Peptides

• Related Pathways :

  Cytoskeleton; Epigenetics; TGF-beta/Smad

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/mans-peptide-tfa.html

• Purity :

  99.88

• Solubility :

  DMSO : 13.3 mg/mL (ultrasonic)

• Smiles :

  CCCCCCCCCCCCCC(NCC(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CCCCN)C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N2[C@@H](CCC2)C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.O=C(C(F)(F)F)O.[x]

• Molecular Formula :

  C111H184N30O35.xC2HF3O2

• Molecular Weight :

  2498.83 (free acid)

• References & Citations :

  [1]Chen CH, et al., A peptide that inhibits function of Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) reduces lung cancer metastasis. Oncogene. 2014 Jul 10;33 (28) :3696-706.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported