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T7 Peptide (TFA)

CAT: 0804-HY-P10323A-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-P10323A-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
T7 peptide (Tumstatin (74-98), human) TFA is an endothelial cell-specific inhibitor. T7 peptide TFA interacts with αVβ3 integrin to inhibit the FAK, PI3-kinase, PKB/Akt, and mTOR signaling pathways in endothelial cells, ultimately suppressing protein synthesis and inducing apoptosis[1].
Product Name Alternative
Tumstatin (74-98), human (TFA)
UNSPSC
12352209
Target
Apoptosis; FAK; Integrin; mTOR
Related Pathways
Apoptosis; Cytoskeleton; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Purity
98.41
Smiles
O=C([C@@H](N)[C@@H](C)O)N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2C(C)C)=O)CC(O)=O)=O)CC(N)=O)=O)C(C)C)=O)CC(N)=O)=O)CSSC[C@H](NC2=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC(C)C)=O)CC3=CNC4=CC=CC=C34)=O)CC5=CC=C(O)C=C5)=O)CO)=O)CC6=CC=C(O)C=C6)=O)CC(O)=O)=O)CC(N)=O)=O)CCCNC(N)=N)=O)CO)=O)C)=O)CC7=CC=CC=C7)=O)CC(N)=O)=O)=O)CC8=CC=CC=C8)=O)CC(C)C)=O)CC9=CC=CC=C9)=O)CCC1)=O)CCSC.O=C(O)C(F)(F)F.[x]
Molecular Formula
C137H189N33O39S3.xC2HF3O2
Molecular Weight
3018.36 (free base)
References & Citations
[1]Maeshima Y, et al. Tumstatin, an endothelial cell-specific inhibitor of protein synthesis. Science. 2002 Jan 4;295 (5552) :140-3.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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