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NKCC2 Antibody

CAT: 0400-SPC-401SSize: 12 µgDry Ice: NoHazardous: No
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CAT#:0400-SPC-401SSize:12 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NKCC2 (Na⁺-K⁺-2Cl⁻ cotransporter 2), encoded by SLC12A1, is a renal-specific transporter located in the thick ascending limb of the loop of Henle. Although classically associated with renal sodium reabsorption and targeted by loop diuretics, NKCC2’s role in the brain is gaining attention. Emerging studies suggest that NKCC2 may influence cerebrospinal fluid composition, neuronal excitability, and osmoregulation. Dysregulation of NKCC2 could contribute to altered ion gradients and excitotoxicity, processes implicated in neurodegenerative diseases such as Alzheimer’s and epilepsy. Understanding NKCC2’s extrarenal functions may uncover novel mechanisms of ion homeostasis and therapeutic opportunities in neurodegeneration.
Description
Rabbit Anti-Rat NKCC2 Polyclonal
CAS Number
9007-83-4
Specifications
Detects ~160kDa.
Product Name Alternative
SLC12A1, sodium potassium chloride cotransporter 2, sodium-potassium-chloride cotransporter isoform 2, BSC1, MBSC1, Na-K-2Cl cotransporter, NKCC2A variant A, RBSC
UNSPSC
12352203
UN Code
Non-hazardous
Hazard Statement
Non-hazardous
Gene ID
25065
Swiss Prot
Q5PQV1
Accession Number
NP_001257546.1
Cellular Locus
Membrane
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Produced against a synthetic peptide mapping to a segment (amino acids 33-55) of the N-terminal tail of rat NKCC2 (antibody designation L224) .
Target
NKCC2
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal
Applications
WB | IHC
Validated Applications
WB, IHC
Field of Research
Cancer | Neuroscience | Pumps/Transporters | Ion Pumps/Transporters
Purification
Protein A Purified
Detection Range
1 µg/ml of SPC-401 was sufficient for detection of NKCC2 in 10 µg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
Concentration
1 mg/ml
Dilution
WB (1:1000) ; IHC (1:25) ; optimal dilutions for assays should be determined by the user.
Weight
0.012
Buffer
PBS, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Caceres P.S., Ares G.R., and Ortiz P.A. (2009) J Biol Chem. 284 (37) : 24965-24971. 2. Xue H., et al. (2009) Neurogastroentrol Motil. 21 (10) : 1068-1089.
Shipping Conditions
Blue Ice or 4ºC
Storage Conditions
-20ºC
Specificity
Detects ~160kDa.
Species
Human | Mouse | Rat
Location
Membrane
Immunogen Species
Rat

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