CD33 splicing modulator 1

• Description:

  CD33 splicing modulator 1 (Compound 1) is a CD33 splicing modulator. CD33/Siglec 3 is a myeloid lineage cell surface receptor that is known to regulate microglia activity. CD33 splicing modulator 1 increases exon 2 skipping in cellular mRNA pools. CD33 splicing modulator 1 has the potential for the research of neurodegenerative disease including Alzheimer's disease[1].

• UNSPSC:

  12352005

• Target:

  Transmembrane Glycoprotein

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/cd33-splicing-modulator-1.html

• Purity:

  99.55

• Solubility:

  DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)

• Smiles:

  CC1=CN2N=CC(C3=CC=C(C=C3F)C(N([C@@H]4CCCNC4)C5=C(C=CC=N5)C)=O)=C2N=C1

• Molecular Formula:

  C25H25FN6O

• Molecular Weight:

  444.50

• References & Citations:

  [1]Chappie TA, et al. Discovery of Small-Molecule CD33 Pre-mRNA Splicing Modulators. ACS Med Chem Lett. 2022;13 (1) :55-62.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2762547-05-5