RNA splicing modulator-4

CAT: 0804-HY-177360-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-177360-01Size:1 mg
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Description
RNA splicing modulator-4 (Compound A) is an orally active, brain-penetrant and selective RNA splicing modulator. RNA splicing modulator-4 regulates the inclusion or exclusion of specific exons in precursor mRNA (pre-mRNA) by modulating alternative splicing events, thereby altering the coding sequence and function of mature mRNAs. RNA splicing modulator-4 is promising for research of neurodegenerative diseases (e.g., Huntington’s disease) and cancers[1].
CAS Number
[3067915-73-2]
UNSPSC
12352005
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Smiles
OC1=C(C2=CC=C(N=N2)N([C@@H]3[C@@H]([C@]4([H])N[C@](CCC4)([H])C3)F)C)C=C5C(N=C(O5)C)=C1
Molecular Formula
C21H24FN5O2
Molecular Weight
397.45
References & Citations
[1]Wester DE POEL, et al. Crystalline forms of 6- (6- (((1r,2r,3s,5s) -2-fluoro-9-azabicyclo[3.3.1]nonan-3-yl) (methyl) amino) pyridazin-3-yl) -2-methylbenzo[d]oxazol-5-ol, a splicing modulator for the treatment of huntington's disease. WO2025006887A1. 2025-01-02.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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