Products for Research Use Only
RegisterLogin

SMN2 splicing modulator TEC-1

CAT: 0013-GTR19213383Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19213383Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
SMN2 splicing modulator TEC-1 is a novel specific, CNS penetrant small molecule SMN2 splicing modulator, increases the expression level of FL-SMN2 mRNA and decreases the expression level of Δ7 mRNA.TEC-1 showed higher selectively (>60-fold) on galactosylceramidase and huntingtin gene expression compared to previously reported compounds (e.g., SMN-C3) due to off-target effects on cryptic exon inclusion and nonsense-mediated mRNA decay.TEC-1 modulates SMN2 splicing and displays disease-modifying effects in motor neurons derived from SMA patient iPSCs (GM24468) .|TEC-1 rescues the phenotype in a murine model of spinal muscular atrophy (SMA) .
CAS Number
2407723-70-8
Field of Research
Signal Transduction
Purity
>98%
Molecular Formula
C21H23N7O
Molecular Weight
389.463
Notes
For research use only.

Related Products

CatalogName
GTR19220831-01RNA splicing modulator 1
GTR19185981CD33 splicing modulator 1
GTR19218086-01CD33 splicing modulator 1 hydrochloride
GTR19220829-01RNA splicing modulator 3
GTR19220830-01RNA splicing modulator 2
GTR19264375-01RNA splicing modulator-4
GTR19274005-01RNA splicing modulator 6
GTR18124092SMN1/SMN2 Antibody
GTR18985623SMN1 / SMN2 Immunizing Peptide
GTR18147182TEC

Alternative Products

CatalogName
bs-60277C-01NVS-SM1 --- SMN2 Splicing Modulator
T74884-01RNA splicing modulator 1
HY-144399-01CD33 splicing modulator 1
HY-144399ACD33 splicing modulator 1 (hydrochloride)
T82763-01CD33 splicing modulator 1 hydrochloride
HY-177360-01RNA splicing modulator-4
T74886-01RNA splicing modulator 3
HY-150247RNA splicing modulator 2
HY-179117RNA splicing modulator 5
TBI5273-25MGRECTAS, pre-mRNA splicing modulator

Popular Products