AZD 4017

• Description :

  AZD 4017 is a potent, selective 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) inhibitor, with an IC50 of 7 nM.

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  11β-HSD

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/AZD_4017.html

• Purity :

  99.20

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  O=C(O)C[C@H]1CN(C2=NC(SCCC)=C(C(NC3CCCCC3)=O)C=C2)CCC1

• Molecular Formula :

  C22H33N3O3S

• Molecular Weight :

  419.58

• Precautions :

  H302

• References & Citations :

  [1]Scott JS, et al. Discovery of a potent, selective, and orally bioavailable acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor: discovery of 2-[ (3S) -1-[5- (cyclohexylcarbamoyl) -6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid (AZD4017) . J Med Chem. 2012 Jun 28;55 (12) :5951-64.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [1024033-43-9]