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BOLD-100

CAT: 0804-HY-16350-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16350-01Size:5 mg
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Description
BOLD-100 (NKP-1339; IT-139) is the first-in-class ruthenium-based anticancer agent in development against solid cancer with limited side effects. BOLD-100 induces G2/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway. BOLD-100 has a high tumor targeting potential, strongly binds to serum proteins such as albumin and transferrin and activates in the reductive tumor milieu[1].
CAS Number
197723-00-5
Product Name Alternative
NKP-1339; IT-139; KP-1339
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bold-100.html
Concentration
10mM
Purity
95.20
Solubility
DMSO : ≥ 59 mg/mL
Smiles
[Cl-][Ru+3]([Cl-])([Cl-])([N]1=CC2=C(N1)C=CC=C2)([N]3=CC4=C(N3)C=CC=C4)[Cl-].[Na+]
Molecular Formula
C14H12Cl4N4NaRu
Molecular Weight
502.14
Precautions
H302, H315, H319, H335
References & Citations
[1]Robert Trondl, et al. NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application. Chemical Science. Chemical Science|[2]Heffeter P, et al. The ruthenium compound KP1339 potentiates the anticancer activity of sorafenib in vitro and in vivo. Eur J Cancer. 2013 Oct;49 (15) :3366-75.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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BA3677-5BOLD-100
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LA8550Bold’s Basal Medium
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