4'-Hydroxytamoxifen (TFA)

• Description :

  4'-Hydroxytamoxifen TFA is a salt form of a metabolite of Tamoxifen. 4'-Hydroxytamoxifen TFA has a higher affinity for ER than Tamoxifen. 4'-Hydroxytamoxifen TFA induces non-apoptotic cytotoxicity in human endometrial adenocarcinoma cells[1].

• UNSPSC :

  12352005

• Target :

  Drug Metabolite; Estrogen Receptor/ERR

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/4-hydroxytamoxifen-tfa.html

• Purity :

  99.43

• Solubility :

  DMSO : 35 mg/mL (ultrasonic)

• Smiles :

  CC/C(C1=CC=C(C=C1)O)=C(C2=CC=C(C=C2)OCCN(C)C)\C3=CC=CC=C3.OC(C(F)(F)F)=O

• Molecular Formula :

  C28H30F3NO4

• Molecular Weight :

  501.54

• References & Citations :

  [1]Cuevas M E, et al. In vitro cytotoxicity of 4'-OH-tamoxifen and estradiol in human endometrial adenocarcinoma cells HEC-1A and HEC-1B[J]. Oncology Reports, 2015, 33 (1) : 464-470.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported