4'-Hydroxytamoxifen (TFA)

CAT: 0804-HY-124414A-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-124414A-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
4'-Hydroxytamoxifen TFA is a salt form of a metabolite of Tamoxifen. 4'-Hydroxytamoxifen TFA has a higher affinity for ER than Tamoxifen. 4'-Hydroxytamoxifen TFA induces non-apoptotic cytotoxicity in human endometrial adenocarcinoma cells[1].
UNSPSC
12352005
Target
Drug Metabolite; Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/4-hydroxytamoxifen-tfa.html
Purity
99.43
Solubility
DMSO : 35 mg/mL (ultrasonic)
Smiles
CC/C(C1=CC=C(C=C1)O)=C(C2=CC=C(C=C2)OCCN(C)C)\C3=CC=CC=C3.OC(C(F)(F)F)=O
Molecular Formula
C28H30F3NO4
Molecular Weight
501.54
References & Citations
[1]Cuevas M E, et al. In vitro cytotoxicity of 4'-OH-tamoxifen and estradiol in human endometrial adenocarcinoma cells HEC-1A and HEC-1B[J]. Oncology Reports, 2015, 33 (1) : 464-470.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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