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4'-Hydroxytamoxifen

CAT: 0804-HY-124414Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-124414Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
4'-Hydroxytamoxifen is a metabolite of Tamoxifen. 4'-Hydroxytamoxifen shows higher affinity for the ER than Tamoxifen. 4'-Hydroxytamoxifen induces a non-apoptotic cytotoxic effect in human endometrial adenocarcinoma cells[1].
CAS Number
82413-23-8
UNSPSC
12352005
Target
Drug Metabolite; Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/4-hydroxytamoxifen-a.html
Purity
99.2
Solubility
DMF : 20 mg/mL (ultrasonic; warming)
Smiles
CC/C(C1=CC=C(C=C1)O)=C(C2=CC=C(C=C2)OCCN(C)C)\C3=CC=CC=C3
Molecular Formula
C26H29NO2
Molecular Weight
387.51
References & Citations
[1]Cuevas ME, et, al. In vitro cytotoxicity of 4'-OH-tamoxifen and estradiol in human endometrial adenocarcinoma cells HEC-1A and HEC-1B. Oncol Rep. 2015 Jan;33 (1) :464-70.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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