4'-Hydroxytamoxifen

• Description :

  4'-Hydroxytamoxifen is a metabolite of Tamoxifen. 4'-Hydroxytamoxifen shows higher affinity for the ER than Tamoxifen. 4'-Hydroxytamoxifen induces a non-apoptotic cytotoxic effect in human endometrial adenocarcinoma cells[1].

• UNSPSC :

  12352005

• Target :

  Drug Metabolite; Estrogen Receptor/ERR

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/4-hydroxytamoxifen-a.html

• Purity :

  99.2

• Solubility :

  DMF : 20 mg/mL (ultrasonic; warming)

• Smiles :

  CC/C(C1=CC=C(C=C1)O)=C(C2=CC=C(C=C2)OCCN(C)C)\C3=CC=CC=C3

• Molecular Formula :

  C26H29NO2

• Molecular Weight :

  387.51

• References & Citations :

  [1]Cuevas ME, et, al. In vitro cytotoxicity of 4'-OH-tamoxifen and estradiol in human endometrial adenocarcinoma cells HEC-1A and HEC-1B. Oncol Rep. 2015 Jan;33 (1) :464-70.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [82413-23-8]