α-Hydroxytamoxifen

• Description:

  α-Hydroxytamoxifen is a metabolite of tamoxifen, reacts with DNA in the absence of metabolizing enzymes, and causes formation of DNA adducts[1].

• Product Name Alternative:

  (E) -α-Hydroxy tamoxifen; α-OHTAM

• UNSPSC:

  12352005

• Hazard Statement:

  H302+H312+H332-H361

• Target:

  Drug Metabolite

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/alpha-hydroxytamoxifen.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(/C(C1=CC=CC=C1)=C(C2=CC=C(C=C2)OCCN(C)C)\C3=CC=CC=C3)O

• Molecular Formula:

  C26H29NO2

• Molecular Weight:

  387.51

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

• References & Citations:

  [1]Phillips DH, et al. alpha-Hydroxytamoxifen, a metabolite of tamoxifen with exceptionally high DNA-binding activity in rat hepatocytes. Cancer Res. 1994 Nov 1;54 (21) :5518-22.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [97151-02-5]