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4-Hydroxytamoxifen

CAT: 0804-HY-16950-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16950-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
4-Hydroxytamoxifen ((Z) -4-Hydroxytamoxifen) is an orally active, selective estrogen receptor modulator (SERM). 4-Hydroxytamoxifen ((Z) -4-Hydroxytamoxifen) is also the active metabolic form of Tamoxifen in vivo and can be used to induce gene knockout in transgenic mice expressing CreER[1][2][3][4].
CAS Number
68047-06-3
Product Name Alternative
(Z) -4-Hydroxytamoxifen; trans-4-Hydroxytamoxifen; (Z) -Afimoxifene
UNSPSC
12352005
Hazard Statement
H305, H360
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/4-Hydroxytamoxifen.html
Purity
99.96
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 20 mg/mL (ultrasonic)
Smiles
CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN(C)C)C=C2)\C3=CC=C(O)C=C3
Molecular Formula
C26H29NO2
Molecular Weight
387.52
Precautions
H305, H360
References & Citations
[1]Jordan VC, et al. A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity. J Endocrinol. 1977 Nov;75 (2) :305-16.|[2]Davis KM, et al. Small molecule-triggered Cas9 protein with improved genome-editing specificity. Nat Chem Biol. 2015 May;11 (5) :316-8.|[3]Kuo YM, et al. 4-Hydroxytamoxifen attenuates methamphetamine-induced nigrostriatal dopaminergic toxicity in intact and gonadetomized mice. J Neurochem. 2003 Dec;87 (6) :1436-43.|[4]Zhang J, et al. Drug Inducible CRISPR/Cas Systems. Comput Struct Biotechnol J. 2019;17:1171-1177.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Estrogen receptor

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