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Tiludronate (disodium)

CAT: 0804-HY-A0213A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-A0213A-01Size:1 mg
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Description
Tiludronate (Tiludronic Acid) disodium, an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H (+) -ATPase. Antiresorptive and anti-inflammatory properties[1][2][3][4].
CAS Number
149845-07-8
Product Name Alternative
Tiludronic acid (disodium)
UNSPSC
12352005
Hazard Statement
H302, H318
Target
Proton Pump
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tiludronate-disodium.html
Purity
99.97
Solubility
H2O : 62.5 mg/mL (ultrasonic)
Smiles
O=P(O)(O[Na])C(P(O)(O[Na])=O)SC1=CC=C(Cl)C=C1
Molecular Formula
C7H7ClNa2O6P2S
Molecular Weight
362.57
Precautions
H302, H318
References & Citations
[1]Reginster JY, et al. Prevention of postmenopausal bone loss by tiludronate. Lancet. 1989 Dec 23-30;2 (8678-8679) :1469-71.|[2]Nunes NLT, et al. Effects of local administration of tiludronic acid on experimental periodontitis in diabetic rats. J Periodontol. 2018 Jan;89 (1) :105-116.|[3]Bonjour JP, et al. Tiludronate: bone pharmacology and safety. Bone. 1995;17 (5 Suppl) :473S-477S.|[4]David P, et al. The bisphosphonate tiludronate is a potent inhibitor of the osteoclast vacuolar H (+) -ATPase. J Bone Miner Res. 1996;11 (10) :1498-1507.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched

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