Tiludronate

• Description :

  Tiludronate (Tiludronic Acid), an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H (+) -ATPase. Antiresorptive and anti-inflammatory properties[1][2][3][4].

• Product Name Alternative :

  Tiludronic acid

• UNSPSC :

  12352005

• Hazard Statement :

  H314

• Target :

  Proton Pump

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/tiludronate.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=P(O)(O)C(P(O)(O)=O)SC1=CC=C(Cl)C=C1

• Molecular Formula :

  C7H9ClO6P2S

• Molecular Weight :

  318.61

• Precautions :

  P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

• References & Citations :

  [1]Reginster JY, et al. Prevention of postmenopausal bone loss by tiludronate. Lancet. 1989;2 (8678-8679) :1469-1471.|[2]Nunes NLT, et al. Effects of local administration of tiludronic acid on experimental periodontitis in diabetic rats. J Periodontol. 2018;89 (1) :105-116.|[3]Bonjour JP, et al. Tiludronate: bone pharmacology and safety. Bone. 1995;17 (5 Suppl) :473S-477S.|[4]David P, et al. The bisphosphonate tiludronate is a potent inhibitor of the osteoclast vacuolar H (+) -ATPase. J Bone Miner Res. 1996;11 (10) :1498-1507.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• CAS Number :

  [89987-06-4]