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Tiludronate

CAT: 0804-HY-A0213Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-A0213Size:1 Each
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Description
Tiludronate (Tiludronic Acid), an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H (+) -ATPase. Antiresorptive and anti-inflammatory properties[1][2][3][4].
CAS Number
89987-06-4
Product Name Alternative
Tiludronic acid
UNSPSC
12352005
Hazard Statement
H314
Target
Proton Pump
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tiludronate.html
Solubility
10 mM in DMSO
Smiles
O=P(O)(O)C(P(O)(O)=O)SC1=CC=C(Cl)C=C1
Molecular Formula
C7H9ClO6P2S
Molecular Weight
318.61
Precautions
P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501
References & Citations
[1]Reginster JY, et al. Prevention of postmenopausal bone loss by tiludronate. Lancet. 1989;2 (8678-8679) :1469-1471.|[2]Nunes NLT, et al. Effects of local administration of tiludronic acid on experimental periodontitis in diabetic rats. J Periodontol. 2018;89 (1) :105-116.|[3]Bonjour JP, et al. Tiludronate: bone pharmacology and safety. Bone. 1995;17 (5 Suppl) :473S-477S.|[4]David P, et al. The bisphosphonate tiludronate is a potent inhibitor of the osteoclast vacuolar H (+) -ATPase. J Bone Miner Res. 1996;11 (10) :1498-1507.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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