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Dde Biotin-PEG4-DBCO

CAT: 0804-HY-140931-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-140931-01Size:5 mg
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Description
Dde Biotin-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Dde Biotin-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
CAS Number
1807512-43-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dde-biotin-peg4-dbco.html
Purity
96.17
Solubility
10 mM in DMSO
Smiles
O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCN/C(CCOCCOCCOCCOCCNC(CCCC[C@H]4[C@](NC5=O)([H])[C@](N5)([H])CS4)=O)=C(C6=O)\C(CC(C)(C)C6)=O
Molecular Formula
C47H61N5O9S
Molecular Weight
872.08
Precautions
H302, H315, H319, H335
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PEG Linkers

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