GP161 rabbit pAb

• Background :

  Upon ligand binding, G protein-coupled receptors, such as GPR161, activate cytoplasmic G proteins (see GNAS, MIM 139320), allowing the receptors to transduce extracellular signals across the plasma membrane into the cell. Phosphorylation of the receptor attenuates signaling (Matteson et al., 2008 [PubMed 18250320]) .[supplied by OMIM, Aug 2008]

• Description :

  Upon ligand binding, G protein-coupled receptors, such as GPR161, activate cytoplasmic G proteins (see GNAS, MIM 139320), allowing the receptors to transduce extracellular signals across the plasma membrane into the cell. Phosphorylation of the receptor attenuates signaling (Matteson et al. 2008 [PubMed 18250320]). [supplied by OMIM, Aug 2008],

• UniProt :

  Q8N6U8

• Swiss Prot :

  Q8N6U8

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  Synthesized peptide derived from human protein . at AA range: 180-260

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight :

  58kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  58kD

• Fragment :

  IgG

• Subcellular Location :

  Cell projection, cilium membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Mainly localizes to primary cilium in a TULP3 and IFT-A complex-dependent manner. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes and is apparently not degraded (By similarity) . .

• Gene ID (Human) :

  23432