JNK2 Rabbit rabbit pAb

CAT: 0855-ES20702-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0855-ES20702-01Size:50 µL

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Background

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternative

Description

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the Cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternative

UniProt

P45984

Swiss Prot

P45984

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant Protein of JNK2

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF

Concentration

1 mg/ml

Dilution

WB 1:500-2000, IHC-p 1:50-300

Molecular Weight

46,54kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

46,54kD

Fragment

IgG

Subcellular Location

Cytoplasm . Nucleus . Colocalizes with POU5F1 in the nucleus. .

Other Product Names

Mitogen-activated protein kinase 9 (MAP kinase 9; MAPK 9; EC 2.7.11.24; JNK-55; Stress-activated protein kinase 1a; SAPK1a; Stress-activated protein kinase JNK2; c-Jun N-terminal kinase 2)

Gene ID (Human)

5601

UniProtKB · P45984

Mitogen-activated protein kinase 9

MK09_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P45984
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: MAPK9
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: MAP kinase 9, MAPK 9
EC number: 2.7.11.24
Processing: —
Secondary accessions: A8K0S3, B5BU66, B5M0B4, D3DWQ8, D3DWQ9, Q15708, Q15710, Q15711, Q8N5C5

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Biological process

Biological rhythms

Cellular component

CytoplasmNucleus

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

PTM

Phosphoprotein

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Alternative Products

Catalog	Name
A0505	JNK2 Rabbit pAb
58910	JNK2 Rabbit mAb
MBS9512781-01	JNK2 Rabbit Rabbit Polyclonal Antibody
APRab12846-01	JNK2 Rabbit Polyclonal Antibody
AF1885	JNK2 Rabbit Monoclonal Antibody