CRY1 rabbit pAb

• Background:

  This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Jan 2014]

• Description:

  This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Jan 2014],

• UniProt:

  Q16526

• Swiss Prot:

  Q16526

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  Synthesized peptide derived from human protein . at AA range: 120-200

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight:

  64kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  64kD

• Fragment:

  IgG

• Subcellular Location:

  Cytoplasm. Nucleus . Translocated to the nucleus through interaction with other clock proteins such as PER2 or ARNTL/BMAL1. .

• Gene ID (Human):

  1407