CD42c rabbit pAb

CAT: 0855-ES8786-02Size: 100 µLDry Ice: NoHazardous: No

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CAT#:0855-ES8786-02Size:100 µL

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Background

Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described; however, t

Description

Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1. 0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described; however, t

UniProt

P13224

Swiss Prot

P13224

Reactivity

Human; Mouse; Rat

Immunogen

Synthetic peptide from human protein at AA range: 90-150

Clonality

Polyclonal

Source

Rabbit

Applications

IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

IHC-p 1:50-200, ELISA 1:10000-20000

Storage Conditions

-20°C/1 year

Fragment

IgG

Subcellular Location

Membrane; Single-pass type I membrane protein.

Other Product Names

Platelet glycoprotein Ib beta chain (GP-Ib beta; GPIb-beta; GPIbB; Antigen CD42b-beta; CD antigen CD42c)

Gene ID (Human)

2812

UniProtKB · P13224

Platelet glycoprotein Ib beta chain

GP1BB_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P13224
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: GP1BB
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: GP-Ib beta, GPIb-beta, GPIbB
EC number: —
Processing: Precursor
Secondary accessions: Q14422, Q8NG40

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

Bernard Soulier syndromeDisease variant

Biological process

Blood coagulationCell adhesionHemostasis

PTM

Disulfide bondGlycoproteinPhosphoprotein

Domain

Leucine-rich repeatSignalTransmembraneTransmembrane helix

Cellular component

Membrane

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