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CPE rabbit pAb

CAT: 0855-ES3897-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES3897-02Size:100 µL
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Background
Carboxypeptidase E (CPE) Homo sapiens This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015]
Description
Carboxypeptidase E (CPE) Homo sapiens This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015],
UniProt
P16870
Swiss Prot
P16870
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from the C-terminal region of human CPE. AA range:427-476
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
53kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
53kD
Fragment
IgG
Subcellular Location
[Isoform 1]: Cytoplasmic vesicle, secretory vesicle . Cytoplasmic vesicle, secretory vesicle membrane ; Peripheral membrane protein . Secreted . Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions. .
Other Product Names
CPE; Carboxypeptidase E; CPE; Carboxypeptidase H; CPH; Enkephalin convertase; Prohormone-processing carboxypeptidase
Gene ID (Human)
1363

UniProtKB · P16870

Carboxypeptidase E

CBPE_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P16870
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CPE
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CPE
EC number
3.4.17.10
Processing
Precursor
Secondary accessions
A8K4N1, B3KR42, B4DFN4, D3DP33, Q9UIU9
Protein keywords

Coding sequence diversity

Alternative splicing

Molecular function

CarboxypeptidaseHydrolaseMetalloproteaseProtease

PTM

Cleavage on pair of basic residuesGlycoproteinZymogen

Cellular component

Cytoplasmic vesicleMembraneSecreted

Disease

Disease variantHypogonadotropic hypogonadismIntellectual disabilityObesity

Ligand

Metal-bindingZinc

Technical term

Proteomics identificationReference proteome

Domain

Signal

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