Products for Research Use Only
RegisterLogin

EPI-001

CAT: 0804-HY-100348-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-100348-02Size:10 mM - 1 mL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
EPI-001, a selective inhibitor of Androgen Receptor (AR), targets transactivation unit 5 (Tau-5) of the AR. EPI-001 can inhibit transactivation of the AR amino-terminal domain (NTD), with an IC50 of ~6 μM. EPI-001 is also a selective modulator of PPARγ. EPI-001 is active against castration-resistant prostate cancer[1][2][3].
CAS Number
227947-06-0
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Androgen Receptor; Apoptosis; PPAR
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/epi-001.html
Purity
99.34
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
OCC(O)COC1=CC=C(C(C)(C2=CC=C(OCC(O)CCl)C=C2)C)C=C1
Molecular Formula
C21H27ClO5
Molecular Weight
394.89
Precautions
H315, H319, H335
References & Citations
[1]Andersen RJ, et, al. Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor. Cancer Cell. 2010 Jun 15; 17 (6) : 535-46.|[2]Brand LJ, et, al. EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer. Oncotarget. 2015 Feb 28; 6 (6) : 3811-24.|[3]Mol ED, et, al. EPI-001, A Compound Active against Castration-Resistant Prostate Cancer, Targets Transactivation Unit 5 of the Androgen Receptor. ACS Chem Biol. 2016 Sep 16;11 (9) :2499-505.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

3-(4-(1-(4-(3-Chloro-2-hydroxypropoxy)phenyl)-1-methylethyl)phenoxy)-1,2-propanediol

Bisphenol A (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) ether is the (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) diether of bisphenol A; a small molecule that inhibits transactivation of the AR amino-terminal domain (NTD). It has a role as an androgen antagonist. It is an organochlorine compound and a diether. It is functionally related to a glycerol and a bisphenol A.

CAS Number227947-06-0
PubChem CID4166922
IUPAC Name3-[4-[2-[4-(3-chloro-2-hydroxypropoxy)phenyl]propan-2-yl]phenoxy]propane-1,2-diol
Molecular FormulaC21H27ClO5
Molecular Weight394.9
XLogP3.3
Topological Polar Surface Area79.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count10
Heavy Atom Count27
Formal Charge0
Complexity403
SMILES
CC(C)(C1=CC=C(C=C1)OCC(CO)O)C2=CC=C(C=C2)OCC(CCl)O
InChI
InChI=1S/C21H27ClO5/c1-21(2,15-3-7-19(8-4-15)26-13-17(24)11-22)16-5-9-20(10-6-16)27-14-18(25)12-23/h3-10,17-18,23-25H,11-14H2,1-2H3
InChIKey
HDTYUHNZRYZEEB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-(4-(1-(4-(3-Chloro-2-hydroxypropoxy)phenyl)-1-methylethyl)phenoxy)-1,2-propanediol
CAS: 227947-06-0
CID: 4166922
Formula: C21H27ClO5
MW: 394.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight394.9
XLogP33.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count10
Exact Mass394.1547017
Monoisotopic Mass394.1547017
Topological Polar Surface Area79.2 Ų
Heavy Atom Count27
Formal Charge0
Complexity403
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-N1286825-Epi-28-epi-cyasterone
HY-N11269Epi-β-amyrin
HY-W016509-01Epi-Inositol
HY-135154Epi-Aszonalenin A
HY-16772-01EPI-743
HY-136968Epi-Doramectin
HY-N3828Epi-Eriocalyxin A
HY-N7265Epi-galantamine
HY-N6711AEpi-Equisetin
HY-P10415-01EPI-X4

Alternative Products

CatalogName
MBS131396EPI-001
A15814-50EPI-001 50mg
A15814-5EPI-001 5mg
A15814-2EPI-001 2mg
A15814-10EPI-001 10mg
A15814-200EPI-001 200mg
A15814-100EPI-001 100mg
A15814-25EPI-001 25mg
A15814-10mM-DEPI-001 10mM * 1mL in DMSO
CS-O-4490517-epi-10-epi-Nandrolone

Popular Products