EPI-X4

• Description:

  EPI-X4 (hSA408–423 peptide) is an antagonist for C-X-C motif chemokine receptor 4 (CXCR4) with IC50 of 8.6 μM. EPI-X4 blocks the CXCL12-mediated signaling, inhibits chemokine-mediated migration and invasion of leukemia cell. EPI-X4 exhibits anti-inflammatory activity in mouse model. EPI-X4 exhibits antiviral activity against CXCR4-tropic HIV with IC50 of 8.6 μM[1].

• Product Name Alternative:

  HSA (408–423) peptide

• UNSPSC:

  12352209

• Target:

  CXCR

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein; Immunology/Inflammation

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Cancer; Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/epi-x4.html

• Purity:

  99.21

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N2[C@@H](CCC2)C(N[C@@H](CCC(N)=O)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N3[C@@H](CCC3)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N

• Molecular Formula:

  C84H144N22O23

• Molecular Weight:

  1830.18

• References & Citations:

  [1]Zirafi O, et al., Discovery and characterization of an endogenous CXCR4 antagonist. Cell Rep. 2015 May 5;11 (5) :737-47.|[2]Kaiser, L. M., et al., (2021) . Targeting of CXCR4 by the Naturally Occurring CXCR4 Antagonist EPI-X4 in Waldenström's Macroglobulinemia. Cancers, 13 (4), 826.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• Isoform:

  CXCR4

• CAS Number:

  930280-31-2