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EPI-743

CAT: 0804-HY-16772-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16772-01Size:5 mg
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Description
EPI-743 (Vatiquinone; α-Tocotrienol quinone; PTC-743; NCT04378075) is a potent cellular oxidative stress protectant, inhibits ferroptosis in cells, which could be used for the study for mitochondrial diseases. EPI-743 is a synthetic analog of vitamin E with oral activity, targets repletion of reduced intracellular glutathione[1][2].
CAS Number
1213269-98-7
Product Name Alternative
α-Tocotrienol quinone; PTC-743; Vatiquinone; NCT04378075
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Ferroptosis; Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/epi-743.html
Purity
98.60
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C(CC[C@](C)(O)CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)=C(C)C(C(C)=C1C)=O
Molecular Formula
C29H44O3
Molecular Weight
440.66
Precautions
H302, H315, H319, H335
References & Citations
[1]Kouga T, et al. Japanese Leigh syndrome case treated with EPI-743. Brain Dev. 2018 Feb;40 (2) :145-149. Brain Dev. 2018 Feb;40 (2) :145-149.|[2]Avula S, et al. Treatment of Mitochondrial Disorders. Curr Treat Options Neurol. 2014. 16:292.|[3]Kahn-Kirby AH, et al. Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy. PLoS One. 2019 Mar 28;14 (3) :e0214250.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3

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