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Epi-galantamine

CAT: 0804-HY-N7265Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N7265Size:1 mg
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Description
Epi-galantamine is a diastereomer of Galantamine. Epi-galantamine is an alkaloid isolated from the bulbs and flowers of Caucasian snowdrop (Galanthus woronowii) . Epi-galantamine inhibits AChE with an EC50 of 45.7 μM[1][2][3].
CAS Number
1668-85-5
UNSPSC
12352005
Hazard Statement
H301-H315-H317-H331
Target
Cholinesterase (ChE)
Type
Natural Products
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/epi-galantamine.html
Solubility
10 mM in DMSO
Smiles
O[C@@H]1C=C[C@@]23CCN(C)CC4=CC=C(OC)C(O[C@@]3([H])C1)=C24
Molecular Formula
C17H21NO3
Molecular Weight
287.35
Precautions
P261-P264-P270-P271-P272-P280-P302+P352-P304+P340-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Thomsen T, et al. Stereoselectivity of cholinesterase inhibition by galanthamine and tolerance in humans. Eur J Clin Pharmacol. 1990;39 (6) :603-5.|[2]Berkov S, et al. Rapid TLC/GC-MS identification of acetylcholinesterase inhibitors in alkaloid extracts. Phytochem Anal. 2008 Sep-Oct;19 (5) :411-9.|[3]Maláková J, et al. High-performance liquid chromatographic method with UV photodiode-array, fluorescence and mass spectrometric detection for simultaneous determination of galantamine and its phase I metabolites in biological samples. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 15;853 (1-2) :265-74.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
AChE

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