UT-B-IN-1

• UNSPSC Description:

  UT-B-IN-1 (UTBINH-14) is a reversible, competitive and selective urea transporter-B (UT-B) inhibitor with IC50 values of 10 and 25 nM for human and mouse UT-B, respectively. UT-B-IN-1 shows low toxicity and high selectivity for UT-B over UT-A isoforms. UT-B-IN-1 increases urine output and reduces urine osmolality of mice. UT-B-IN-1 can be used for diuretic mechanism research[1].

• Target Antigen:

  Urea Transporter

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/ut-b-in-1.html

• Purity:

  99.68

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=S(C1=C2N=C(NCC3=CC=CS3)C4=C(C=CS4)N2N=N1)(C5=CC=C(CC)C=C5)=O

• Molecular Weight:

  455.58

• References & Citations:

  [1]Yao C, et al. Triazolothienopyrimidine inhibitors of urea transporter UT-B reduce urine concentration. J Am Soc Nephrol. 2012 Jul;23(7):1210-20.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  892742-76-6