UT-11

• Description :

  UT-11 is a potent and brain-permeable microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with IC50s of 0.10 μM and 2.00 μM for inhibiting PGE2 production in human (SK-N-AS) and murine (BV2) cells, respectively[1].

• UNSPSC :

  12352005

• Target :

  PGE synthase

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/ut-11.html

• Concentration :

  10mM

• Purity :

  99.62

• Solubility :

  DMSO : 25 mg/mL (ultrasonic; warming; heat to 80°C)

• Smiles :

  O=C(C1CCN(CC1)C2=NC3=C(S2)C=C(C(Cl)=C3)Cl)N[C@@H]4CCOC4

• Molecular Formula :

  C17H19Cl2N3O2S

• Molecular Weight :

  400.32

• References & Citations :

  [1]Sluter MN, et al. Novel, Brain-Permeable, Cross-Species Benzothiazole Inhibitors of Microsomal Prostaglandin E Synthase-1 (mPGES-1) Dampen Neuroinflammation In Vitro and In Vivo. ACS Pharmacol Transl Sci. 2023 Mar 21;6 (4) :587-599.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported