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UT-11

CAT: 0804-HY-149202-01Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-149202-01Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UT-11 is a potent and brain-permeable microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with IC50s of 0.10 μM and 2.00 μM for inhibiting PGE2 production in human (SK-N-AS) and murine (BV2) cells, respectively[1].
UNSPSC
12352005
Target
PGE synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ut-11.html
Concentration
10mM
Purity
99.62
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C(C1CCN(CC1)C2=NC3=C(S2)C=C(C(Cl)=C3)Cl)N[C@@H]4CCOC4
Molecular Formula
C17H19Cl2N3O2S
Molecular Weight
400.32
References & Citations
[1]Sluter MN, et al. Novel, Brain-Permeable, Cross-Species Benzothiazole Inhibitors of Microsomal Prostaglandin E Synthase-1 (mPGES-1) Dampen Neuroinflammation In Vitro and In Vivo. ACS Pharmacol Transl Sci. 2023 Mar 21;6 (4) :587-599.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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