CTSL/B-IN-1

CTSL/B-IN-1

• UNSPSC Description: CTSLCTSB-IN-1 (compound 212-148) is a bispecific inhibitor of host viral spike cleaver proteins CTSL/CTSB and TMPRSS2 with IC50s of 2.13/64.07 nM and 1.38 μM, respectively. CTSLCTSB-IN-1 blocks two relevant SARS-CoV-2 viral entry pathways by inhibiting the viral spike cleavage and can be applied to anti-SARS-CoV-2 research[1].
• Target Antigen: Cathepsin; SARS-CoV
• Type: Reference compound
• Related Pathways: Anti-infection;Metabolic Enzyme/Protease
• Applications: COVID-19-anti-virus
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/ctsl-b-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N[C@H](C(N[C@@H](CCC1=CC=CC=C1)/C=C/S(=O)(C2=CC=CC=C2)=O)=O)CC3=CC=CC=C3)N(CC4)CCN4CCOC(C5=CC=C(C=C5)/N=C(N)\N)=O
• Molecular Weight: 765.92
• References & Citations: [1]Haitao Yang, et al. Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry. Nat Commun,.2023，14，7574.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported