UT-34

CAT: 0804-HY-136242-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-136242-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

UT-34 is a potent, selective, orally bioactive second-generation pan-androgen receptor (AR) antagonist and degrader, with IC50 values of 211.7 nM, 262.4 nM, and 215.7 nM for wild-type AR, F876L-AR, and W741L-AR, respectively. UT-34 binds to the ligand-binding domain (LBD) and functional 1 (AF-1) domain of AR and requires the ubiquitin-proteasome pathway for AR degradation. UT-34 has anti-prostate cancer effects.

CAS Number

2168525-92-4

UNSPSC

12352005

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/ut-34.html

Purity

98.09

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=C(C#N)C(C(F)(F)F)=C1)[C@@](C)(O)CN2N=CC(F)=C2

Molecular Formula

C15H12F4N4O2

Molecular Weight

356.27

References & Citations

[1]Ponnusamy S, et al. Orally Bioavailable Androgen Receptor Degrader, Potential Next-Generation Therapeutic for Enzalutamide-Resistant Prostate Cancer. Clin Cancer Res. 2019 Nov 15;25 (22) :6764-6780.|[2]Stone L. UT-34: a promising new AR degrader. Nat Rev Urol. 2019 Nov;16 (11) :640.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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Catalog	Name
BA9176-5	UT-34
BA9182-5.1	UT-155
GTR19220933-01	UT-11
GTR19236641	UT-59

UT-34

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