DPI-4452

CAT: 0804-HY-P10761-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-P10761-01Size:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
DPI-4452 is a CAIX-targeting cyclic peptide with a DOTA cage, and can be chelated with radionuclide for CAIX-expressing tumor PET-CT imaging and study. DPI-4452 specifically and selectively binds CAIX without interaction with an in vitro off-target receptor panel of 55 targets (IC50 for recombinant hCAIX: 130 nM) . Radiolabeled DPI-4452 inhibits tumor growth in HT-29 and SK-RC-52 xenograft mouse models[1]. DPI-4452 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs) .
CAS Number
[2941391-49-5]
UNSPSC
12352209
Target
Carbonic Anhydrase; Radionuclide-Drug Conjugates (RDCs)
Type
Peptides
Related Pathways
Antibody-drug Conjugate/ADC Related; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dpi-4452.html
Purity
98.27
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C[C@@H](O)[C@H](NC([C@@H](N1)CC(C)C)=O)C(N[C@@H](CC2=CNC3=C2C=CC=C3)C(N[C@H](C(N[C@@H](CSCC4=CC(CSC[C@H](NC([C@@H](NC(CN5CCN(C(CN(CCN6CC(O)=O)CCN(CCN(CC(O)=O)CC6)CC(O)=O)=O)CC5)=O)CCC(N)=O)=O)C(N[C@@H](CCC(O)=O)C(N(CCC7)[C@H]7C(N[C@@H](CC(O)=O)C(N[C@@H](CC8=CC=CC(NC(CCCS(=O)(N)=O)=O)=C8)C1=O)=O)=O)=O)=O)=CC=C4)C(N)=O)=O)CO)=O)=O
Molecular Formula
C92H132N22O29S3
Molecular Weight
2106.36
References & Citations
[1]1. Massière, et al. Preclinical Characterization of DPI-4452: A68Ga/177Lu Theranostic Ligand for Carbonic Anhydrase IX. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2024, 65 (5), 761–767.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
CA IX

Related Products

CatalogName
HY-157479DPI-2016
HY-19231DPI-3290
HY-156988DPI-287
HY-19666-01DPI 201-106
HY-R01058-01Hsa-miR-4452 mimic
HY-19666RDPI 201-106 (Standard)
HY-R01058A-01Hsa-miR-4452 agomir
HY-RI01058-01Hsa-miR-4452 inhibitor
HY-RI01058A-01Hsa-miR-4452 antagomir
HY-126322-01DVD-445

Alternative Products

CatalogName
T201920-01DPI-4452
MBS3840005-01DPI-3290
T86300-01DPI-287
T86299-01DPI-2016
MBS3616452-01DPI 201-106
A13699-25DPI-3290 25mg
526434DPI-201-106
A13699-50DPI-3290 50mg
A13699-5DPI-3290 5mg
C18206DPI (Diphenyleneiodonium chloride)

Popular Products