DVD-445

• Description:

  DVD-445 (Compound 7) is a potent peptidomimetic covalent thioredoxin reductase 1 (TrxR1) inhibitor with an IC50 of 0.60 μM for rat TrxR1. DVD-445 has good anticancer application[1].

• UNSPSC:

  12352005

• Target:

  TrxR

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/dvd-445.html

• Concentration:

  10mM

• Purity:

  98.36

• Solubility:

  DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C(OCCN(C(C1=CC=C(F)C=C1)C(NC(C)(C)C)=O)C)/C=C/C(C2=CC=C(F)C=C2)=O

• Molecular Formula:

  C25H28F2N2O4

• Molecular Weight:

  458.50

• References & Citations:

  [1]Jovanović M, et al. Novel electrophilic amides amenable by the Ugi reaction perturb thioredoxin system via thioredoxin reductase 1 (TrxR1) inhibition: Identification of DVD-445 as a new lead compound for anticancer therapy. Eur J Med Chem. 2019 Aug 1;181:111580.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2375846-41-4