Gln-AMS

• Description :

  Gln-AMS is an aminoacyl-tRNA synthetases (AARS) inhibitor, which binds the A-domain within the NRPS enzymes.

• UNSPSC :

  12352005

• Target :

  Aminoacyl-tRNA Synthetase; Bacterial

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/Gln-AMS.html

• Purity :

  98.71

• Solubility :

  DMSO : 120 mg/mL (ultrasonic)

• Smiles :

  NC1=C2N=CN([C@@H]3O[C@H](COS(=O)(NC([C@@H](N)CCC(N)=O)=O)=O)[C@@H](O)[C@H]3O)C2=NC=N1

• Molecular Formula :

  C15H22N8O8S

• Molecular Weight :

  474.45

• References & Citations :

  [1]Fang P, et al. Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase. Nat Commun. 2015 Mar 31;6:6402.|[2]Atta-ur-Rahman, et al. Frontiers in Natural Product Chemistry.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [209543-57-7]