Glu-AMS (TEA)

• Description:

  Glu-AMS TEA is a competitive inhibitor of Escherichia coli glutamyl-tRNA synthetase (GluRS), with the Ki of 2.8 nM[1].

• UNSPSC:

  12352005

• Target:

  Aminoacyl-tRNA Synthetase; Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Metabolic Enzyme/Protease

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/glu-ams-tea.html

• Purity:

  90.15

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CCN(CC)CC.O[C@H]1[C@@H](O)[C@H](N2C=NC3=C(N)N=CN=C32)O[C@@H]1COS(NC([C@@H](N)CCC(O)=O)=O)(=O)=O

• Molecular Formula:

  C21H36N8O9S

• Molecular Weight:

  576.62

• References & Citations:

  [1]Sébastien P Blais, et al. tRNAGlu Increases the Affinity of Glutamyl-tRNA Synthetase for Its Inhibitor Glutamyl-Sulfamoyl-Adenosine, an Analogue of the Aminoacylation Reaction Intermediate Glutamyl-AMP: Mechanistic and Evolutionary Implications. PLoS One. 2015 Jun 3;10 (6) :e0130238.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1810728-44-9]