Arg-AMS

• Description:

  Arg-AMS (compound 24) is a potent nanomolar inhibitor of arginyl tRNA synthetase, which displays tightly bound inhibitory characteristics for the A-domains in non-ribosomal peptide synthetases (NRPS) enzymes[1].

• UNSPSC:

  12352005

• Target:

  Aminoacyl-tRNA Synthetase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/Arg-AMS.html

• Purity:

  98.0

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  NC1=C2N=CN([C@@H]3O[C@H](COS(=O)(NC([C@@H](N)CCCNC(N)=N)=O)=O)[C@@H](O)[C@H]3O)C2=NC=N1

• Molecular Formula:

  C16H26N10O7S

• Molecular Weight:

  502.51

• References & Citations:

  [1]Kasai S, et al. Functional profiling of adenylation domains in nonribosomal peptide synthetases by competitive activity-based protein profiling. Chem Commun (Camb) . 2015 Nov 11;51 (87) :15764-7.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [301351-95-1]