Arg-AMS

• Description :

  Arg-AMS (compound 24) is a potent nanomolar inhibitor of arginyl tRNA synthetase, which displays tightly bound inhibitory characteristics for the A-domains in non-ribosomal peptide synthetases (NRPS) enzymes[1].

• CAS Number :

  [301351-95-1]

• UNSPSC :

  12352005

• Target :

  Aminoacyl-tRNA Synthetase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/Arg-AMS.html

• Purity :

  98.0

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  NC1=C2N=CN([C@@H]3O[C@H](COS(=O)(NC([C@@H](N)CCCNC(N)=N)=O)=O)[C@@H](O)[C@H]3O)C2=NC=N1

• Molecular Formula :

  C16H26N10O7S

• Molecular Weight :

  502.51

• References & Citations :

  [1]Kasai S, et al. Functional profiling of adenylation domains in nonribosomal peptide synthetases by competitive activity-based protein profiling. Chem Commun (Camb) . 2015 Nov 11;51 (87) :15764-7.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported