AM-2394

• Description:

  AM-2394 is a structurally distinct glucokinase activator (GKA) . AM-2394 activates glucokinase (GK) with an EC50 of 60 nM.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Glucokinase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/AM-2394.html

• Purity:

  99.30

• Solubility:

  DMSO : ≥ 30 mg/mL

• Smiles:

  O=C(NC)NC1=CC(OC2=CC(C)=CN=C2)=C(C3=CC=C(OCC(C)(O)C)N=C3)C=N1

• Molecular Formula:

  C22H25N5O4

• Molecular Weight:

  423.47

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Dransfield PJ, et al. Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394. ACS Med Chem Lett. 2016 May 23;7 (7) :714-8.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1442684-77-6]