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AM-6226

CAT: 0804-HY-120493ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-120493ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AM-6226 is a potent and orally active G protein coupled receptor 40 (GPR40) full agonist with an EC50 of 0.12 μM. AM-6226 can activate the GPR40 receptors on pancreatic β cells and enteroendocrine L cells, promote insulin secretion in a glucose-dependent manner and also increase the release of incretin hormones (GLP-1, GIP), thereby avoiding the risk of hypoglycemia. AM-6226 can be used for the research of metabolic disease, such as diabetes[1].
CAS Number
1449742-87-3
UNSPSC
12352005
Target
Free Fatty Acid Receptor
Related Pathways
GPCR/G Protein
Field of Research
Metabolic Disease
Smiles
CC1([C@@H](CCC1)C2=C(C3=CC(OC)=CC=C3F)C=CC(COC4=C(C([C@H](CC)CC(O)=O)=CC=C4)F)=C2)C
Molecular Formula
C32H36F2O4
Molecular Weight
522.62
References & Citations
[1]Brown SP, et al. Discovery of AM-6226: A Potent and Orally Bioavailable GPR40 Full Agonist That Displays Efficacy in Nonhuman Primates. ACS Med Chem Lett. 2018 Jun 6;9 (7) :757-760.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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