AM-6226

• Description:

  AM-6226 is a potent and orally active G protein coupled receptor 40 (GPR40) full agonist with an EC50 of 0.12 μM. AM-6226 can activate the GPR40 receptors on pancreatic β cells and enteroendocrine L cells, promote insulin secretion in a glucose-dependent manner and also increase the release of incretin hormones (GLP-1, GIP), thereby avoiding the risk of hypoglycemia. AM-6226 can be used for the research of metabolic disease, such as diabetes[1].

• UNSPSC:

  12352005

• Target:

  Free Fatty Acid Receptor

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Metabolic Disease

• Smiles:

  CC1 ([C@@H] (CCC1) C2=C (C3=CC (OC) =CC=C3F) C=CC (COC4=C (C ([C@H] (CC) CC (O) =O) =CC=C4) F) =C2) C

• Molecular Formula:

  C32H36F2O4

• Molecular Weight:

  522.62

• References & Citations:

  [1]Brown SP, et al. Discovery of AM-6226: A Potent and Orally Bioavailable GPR40 Full Agonist That Displays Efficacy in Nonhuman Primates. ACS Med Chem Lett. 2018 Jun 6;9 (7) :757-760.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1449742-87-3