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GDC-2394

CAT: 0013-GTR19210271-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19210271-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GDC-2394 is a potent and selective orally bioavailable NLRP3 inflammasome inhibitor that also directly suppresses IL-1β. It demonstrates species-specific IC50 values of 0.4 μM (human) and 0.1 μM (mouse) for IL-1β and selectively blocks NLRP3-mediated caspase-1 activation without affecting NLRC4. This profile makes it a valuable tool for investigating NLRP3-driven pathologies in both cellular and animal models of inflammatory and autoimmune diseases.
CAS Number
2238822-07-4
Field of Research
Cell Biology, Immunology & Inflammation, Protein Biochemistry
Smiles
N (C (NS (=O) (=O) C1=C2N (N=C1) C[C@H] (NC) CO2) =O) C3=C4C (=CC5=C3CCC5) CCC4
Molecular Formula
C20H25N5O4S
Molecular Weight
431.51
Storage Conditions
-20°C
Notes
For research use only.

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