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AM-001

CAT: 0804-HY-126133-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-126133-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AM-001 is a non-competitive inhibitor of Epac1 that blocks the activation of Rap1, a downstream effector of Epac1, in cultured cells. AM-001 can be used in heart disease-related research[1].
CAS Number
340817-81-4
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Field of Research
Cardiovascular Disease; Others
Assay Protocol
https://www.medchemexpress.com/am-001.html
Purity
99.95
Solubility
DMSO : 1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
NC1=C(C(NC2=CC=C(F)C=C2)=O)SC3=C1C(C4=CC=CC=C4)=CC(C5=CC=CS5)=N3
Molecular Formula
C24H16FN3OS2
Molecular Weight
445.53
References & Citations
[1]Laudette M, et al. Identification of a pharmacological inhibitor of Epac1 that protects the heart against acute and chronic models of cardiac stress. Cardiovasc Res. 2019 Oct 1;115 (12) :1766-1777.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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