Products for Research Use Only
RegisterLogin

PF-DcpSi

CAT: 0804-HY-122604-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-122604-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
PF-DcpSi is a mRNA decapping scavenger enzyme (DcpS) inhibitor (IC50: 0.11 nM) . PF-DcpSi (30 mg/kg, i.p.) ameliorates the disease phenotype in a mice model of spinal muscular atrophy (SMA) [1].
CAS Number
2092917-19-4
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pf-dcpsi.html
Purity
98.0
Smiles
N#CC1=CC(F)=CC(OCC2=CC=CC3=NC(N)=NC(N)=C23)=C1
Molecular Formula
C16H12FN5O
Molecular Weight
309.30
References & Citations
[1]Gopalsamy A, et al. Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA) . J Med Chem. 2017 Apr 13;60 (7) :3094-3108.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Phase 1

Related Products

CatalogName
HY-P991635PF-07329640
HY-P990645-01PF-03732010
HY-171821-01PF-08046054
HY-123803PF-06807656
HY-120195PF-04677490
HY-108338PF-05139962
HY-108327PF-05020182
HY-19530-01PF-2771
HY-10721-01PF-AKT400
HY-125415-01PF-4693627

Alternative Products

CatalogName
MBS3603280PF-DcpSi
MBS579460PF-03084014 (PF-3084014)
BA5950-5.1PF-06928215
BA7028-5PF-4840154
B5563-10PF 5081090
BA8315-10PF-06747711
C4756-10PF-622
A4689-10PF-06409577
BA1871-5.1PF-4878691
BA7829-5.1PF-06840003

Popular Products