PF-DcpSi

• Description :

  PF-DcpSi is a mRNA decapping scavenger enzyme (DcpS) inhibitor (IC50: 0.11 nM) . PF-DcpSi (30 mg/kg, i.p.) ameliorates the disease phenotype in a mice model of spinal muscular atrophy (SMA) [1].

• UNSPSC :

  12352005

• Target :

  DNA/RNA Synthesis

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/pf-dcpsi.html

• Purity :

  98.0

• Smiles :

  N#CC1=CC(F)=CC(OCC2=CC=CC3=NC(N)=NC(N)=C23)=C1

• Molecular Formula :

  C16H12FN5O

• Molecular Weight :

  309.30

• References & Citations :

  [1]Gopalsamy A, et al. Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA) . J Med Chem. 2017 Apr 13;60 (7) :3094-3108.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [2092917-19-4]