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MDL 72527 (free base)

CAT: 0804-HY-W680647Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W680647Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MDL 72527 free base is a potent polyamine oxidase (PAO) inhibitor. MDL 72527 free base shows a lysosomotropic effect. MDL 72527 shows neuroprotective effects[1][2].
CAS Number
99207-33-7
UNSPSC
12352211
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mdl-72527-free-base.html
Smiles
C=C=CCNCCCCNCC=C=C
Molecular Formula
C12H20N2
Molecular Weight
192.30
References & Citations
[1]Doğan A, et al. Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion. J Neurochem. 1999 Feb;72 (2) :765-70.|[2]Agostinelli E, et al. Toxicity of enzymatic oxidation products of spermine to human melanoma cells (M14) : sensitization by heat and MDL 72527. Biochim Biophys Acta. 2006 Oct;1763 (10) :1040-50.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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