Tau-aggregation and neuroinflammation-IN-1

CAT:

804-HY-146005-05

Size:

50 mg

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CAS Number: 2175953-98-5
UNSPSC Description: Tau-aggregation and neuroinflammation-IN-1 is a potent tau-aggregation and neuroinflammation inhibitor. Tau-aggregation and neuroinflammation-IN-1 exhibits remarkable inhibitory activities against AcPHF6 and full-length tau aggregation. Tau-aggregation and neuroinflammation-IN-1 has a low cytotoxicity and reduced NO release in LPS-stimulated BV2 cells. Tau-aggregation and neuroinflammation-IN-1 can reverse okadaic acid-induced memory impairment in rats[1].
Target Antigen: Microtubule/Tubulin
Type: Reference compound
Related Pathways: Cell Cycle/DNA Damage;Cytoskeleton
Applications: COVID-19-immunoregulation
Field of Research: Inflammation/Immunology; Neurological Disease
Assay Protocol: https://www.medchemexpress.com/tau-aggregation-and-neuroinflammation-in-1.html
Solubility: DMSO : 125 mg/mL (ultrasonic)
Smiles: O=C(O)C1=CC=C(N2N=C(C)C3=C2C=C(OC4=C(C(C)=O)C(O)=C(C)C(O)=C45)[C@]5(C)C3=O)C=C1
Molecular Weight: 460.44
References & Citations: [1]Shi CJ, Peng W, Zhao JH, et al. Usnic acid derivatives as tau-aggregation and neuroinflammation inhibitors. Eur J Med Chem. 2020;187:111961.
Shipping Conditions: Room Temperature
Clinical Information: No Development Reported

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