Aβ/tau aggregation-IN-1

Aβ/tau aggregation-IN-1

• CAS Number: 2252162-81-3
• UNSPSC Description: Aβ/tau aggregation-IN-1 is a potent Aβ1-42 β-sheets formation and tau aggregation inhibitor. The KD values of Aβ/tau aggregation-IN-1 with Aβ1-42 and tau are 160 μM and 337 μM, respectively. Aβ/tau aggregation-IN-1 can permeate the blood-brain barrier[1].
• Target Antigen: Amyloid-β
• Type: Reference compound
• Related Pathways: Neuronal Signaling
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/aβ-tau-aggregation-in-1.html
• Solubility: DMSO : 33.33 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: NC1=C2C(CC/C(C2=O)=C\C3=CC=CC4=C3C=CC=C4)=[N+](C5=CC=CC=C51)C.[I-]
• Molecular Weight: 492.35
• References & Citations: [1] Lv P, et al. Synthesis and evaluation of 1,2,3,4-tetrahydro-1-acridone analogues as potential dual inhibitors for amyloid-beta and tau aggregation. Bioorg Med Chem. 2018;26(16):4693-4705.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported