PROTAC ERRα Degrader-1

• Description :

  PROTAC ERRα Degrader-1 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRα Degrader-1 is an PROTAC estrogen-related receptor alpha (ERRa) degrader[1].

• UNSPSC :

  12352005

• Target :

  Estrogen Receptor/ERR; PROTACs

• Type :

  Reference compound

• Related Pathways :

  PROTAC; Vitamin D Related/Nuclear Receptor

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/protac-erralpha-degrader-1.html

• Purity :

  98.22

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(N1CC(N(CC(NCCNC(/C(C#N)=C/C2=CC(OC)=C(OCC3=C(C=C(C(F)(F)F)C=C3)C(F)(F)F)C=C2)=O)=O)CC1)=O)N4[C@@H](C5=CC=C(Cl)C=C5)[C@@H](C6=CC=C(Cl)C=C6)N=C4C7=C(C=C(OC)C=C7)OC(C)C

• Molecular Formula :

  C54H49Cl2F6N7O8

• Molecular Weight :

  1108.91

• References & Citations :

  [1]Peng L, et al. Identification of New Small-Molecule Inducers of Estrogen-related Receptor α (ERRα) Degradation. ACS Med Chem Lett. 2019 Apr 12;10 (5) :767-772.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, stored under nitrogen, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• Isoform :

  ERRα; MDM2

• CAS Number :

  [2306388-84-9]