MG-B-28

• Description:

  MG-B-28 is an inhibitor of BTLA-HVEM with an IC50 value of 906 nM. MG-B-28 promotes T-cell activation in a dose-dependent manner by blocking the BTLA-HVEM interaction[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/mg-b-28.html

• Smiles:

  COC1=CC=C([C@@H](C#N)N2CCN(C(C(C3=C4C=CC=C3)=NN(C5=CC=CC=C5)C4=O)=O)CC2)C=C1

• Molecular Formula:

  C28H25N5O3

• Molecular Weight:

  479.53

• References & Citations:

  [1]Abdel-Rahman S A, et al. Small molecules from antibody pharmacophores (SMAbPs) as a hit identification workflow for immune checkpoints[J]. Science Advances, 2024, 10 (42) : eadq5540.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported