Cbl-b-IN-28

• Description:

  Cbl-b-IN-28 (Compound B2) is an orally active Cbl-b inhibitor. Cbl-b-IN-28 promotes the secretion of cytokines such as IL-2 and enhances the function of immune cells by regulating the phosphorylation levels of key proteins in the T-cell receptor signaling pathway. Cbl-b-IN-28 can be used in research in the field of cancer immunology[1].

• UNSPSC:

  12352005

• Target:

  E1/E2/E3 Enzyme; Interleukin Related

• Related Pathways:

  Immunology/Inflammation; Metabolic Enzyme/Protease

• Field of Research:

  Cancer; Inflammation/Immunology

• Smiles:

  C[C@@H]1CCCN(CC2=CC(C(C(F)(F)F)=CN(C3=CC=CC(C4(CC(C)C4)C5=NN=CN5C)=C3)C6=O)=C6N2)C1

• Molecular Formula:

  C29H33F3N6O

• Molecular Weight:

  538.61

• References & Citations:

  [1]Zhang Y, et al. Rational design, optimization, and biological evaluation of novel pyrrolo-pyridone derivatives as potent and orally active Cbl-b inhibitors. Eur J Med Chem. 2025 Jun 5;290:117488.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported