Products for Research Use Only
RegisterLogin

Cbl-b-IN-28

CAT: 0804-HY-173311Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-173311Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Cbl-b-IN-28 (Compound B2) is an orally active Cbl-b inhibitor. Cbl-b-IN-28 promotes the secretion of cytokines such as IL-2 and enhances the function of immune cells by regulating the phosphorylation levels of key proteins in the T-cell receptor signaling pathway. Cbl-b-IN-28 can be used in research in the field of cancer immunology[1].
UNSPSC
12352005
Target
E1/E2/E3 Enzyme; Interleukin Related
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Cancer; Inflammation/Immunology
Smiles
C[C@@H]1CCCN(CC2=CC(C(C(F)(F)F)=CN(C3=CC=CC(C4(CC(C)C4)C5=NN=CN5C)=C3)C6=O)=C6N2)C1
Molecular Formula
C29H33F3N6O
Molecular Weight
538.61
References & Citations
[1]Zhang Y, et al. Rational design, optimization, and biological evaluation of novel pyrrolo-pyridone derivatives as potent and orally active Cbl-b inhibitors. Eur J Med Chem. 2025 Jun 5;290:117488.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-179575Cbl-b-IN-29
HY-159615Cbl-b-IN-21
HY-163194Cbl-b-IN-16
HY-169005Cbl-b-IN-27
HY-156764Cbl-b-IN-8
HY-158174Cbl-b-IN-20
HY-156768-01Cbl-b-IN-12
HY-156763Cbl-b-IN-7
HY-161977-01Cbl-b-IN-26
HY-155477-01Cbl-b-IN-15

Alternative Products

CatalogName
GTR19258489-01Cbl-b-IN-28
sc-376409Cbl-b (B-5)
BA7372-1Cbl-b-IN-1
BA7392-25Cbl-b-IN-5
T209801-01Cbl-b-IN-20
T209659-01Cbl-b-IN-17
T209172-01Cbl-b-IN-16
T200325-01Cbl-b-IN-26
T79900-01Cbl-b-IN-13
T79899-01Cbl-b-IN-12

Popular Products